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Bl22 with hairy cell leukemia

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Robert J. Kreitman, MD, chief, Clinical Immunology Section, Laboratory of Molecular Biology, National Cancer Institute, reported that 13 of 16 patients with hairy cell leukemia responded to BL22, and 11 achieved a complete remission, most of them long-lasting. The agent was tested in about 30 patients with various chemotherapy-resistant B-cell malignancies. Patients do not stop relapsing over time," Dr.
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Retreatment Protocol for BL22 Immunotherapy in Relapsed or Refractory Hairy Cell Leukemia

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Clinical Trial on Hairy Cell Leukemia: BL22 (CAT) - Clinical Trials Registry - ICH GCP

Study record managers: refer to the Data Element Definitions if submitting registration or results information. BL22 is a type of protein that scientists have created to interact with certain cancer cells. Experiments have shown that BL22 can bind with cancer cells that have a particular kind of protein called CD22 on their surface, and can kill those cells. CD22 is present on certain types of hairy cell leukemia HCL cancer cells, and researchers have been working on treatments that will use BL22 and other related proteins to interact with and kill these kinds of cancer cells. The primary purpose of this study will be to provide access to and treatment with BL22 for patients who have HCL in order to determine their response to the treatment. In addition, the study will assess potential side effects of BL22 and examine why some patients respond better than others to treatment with BL22 and related therapies. This study will include about 21 to 25 adults who have been diagnosed with forms of HCL that have not responded well to standard treatments such as surgery, chemotherapy, or radiation therapy.
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Hairy Cell Leukemia Responds to New Compound, BL22

BL22 is a type of protein that scientists have created to interact with certain cancer cells. Experiments have shown that BL22 can bind with cancer cells that have a particular kind of protein called CD22 on their surface, and can kill those cells. CD22 is present on certain types of hairy cell leukemia HCL cancer cells, and researchers have been working on treatments that will use BL22 and other related proteins to interact with and kill these kinds of cancer cells.
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Results from an early-phase clinical trial evaluating an innovative form of treatment involving a toxin from bacteria has demonstrated high anti-cancer activity in patients with hairy cell leukemia, as recently reported in the New England Journal of Medicine. These results are consistent with results from preliminary trials evaluating BL Hairy cell leukemia is a cancer that involves the blood and bone marrow.
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