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Defecation of a “colon cast” as a rare presentation of acute graft-versus-host disease

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Human anus - Wikipedia

In humans , the anus from Latin anus meaning "ring", "circle" [1] [2] is the external opening of the rectum. Two sphincters control the exit of feces from the body during an act of defecation , which is the primary function of the anus. These are the internal anal sphincter and the external anal sphincter , which are circular muscles that normally maintain constriction of the orifice and which relaxes as required by normal physiological functioning. The inner sphincter is involuntary and the outer is voluntary.
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Full Cast & Crew

Diffuse involvement of the gastrointestinal tract by graft versus host disease GVHD is a common complication of allogeneic hematopoietic stem cell transplant HSCT. Gastrointestinal GVHD usually presents 3 or more weeks after HSCT and is characterized by profuse diarrhea, anorexia, nausea, vomiting, abdominal pain and gastrointestinal bleeding. The patient was treated with methylprednisolone, cyclosporin and mycophenolate mofetil, with a partial response diarrhea and abdominal pain improved , but then he developed multiple other medical complications and died after 3 months. Acute graft-versus-host disease GVHD occurs after allogeneic hematopoietic stem cell IA transplantation HSCT as a consequence of an immune reaction by the donor immune cells against host tissues. The spontaneous passage of a full-thickness colon cast has been described eight times previously, 5 — 9 including one case of a mucosal cast.
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